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Madras et al (2006) in a very recent paper demonstrated in vivo binding of modafinil to striatal DAT and thalamic NET in rhesus monkeys utilizing PET imaging. The investigators in contrast binding of the DAT probe [11C]CFT and the Web probe [11C]MeNER while in the absence of modafinil with the binding of these probes in the existence of modafinil t